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• The effect of oral curcumin supplementation and immobilization on skeletal muscle fiber diameter of rattus norvegicus

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  The effect of oral curcumin supplementation and immobilization on skeletal muscle fiber diameter of rattus norvegicus

  Author(s)

  Pawana IPA, Haryadi RD

  Date

  2008-01-15

  Source

  Media Folia Medica Indonesiana

  Immobilization may result in skeletal muscle atrophy, in which the diameter of muscle fiber is decreased.
  The stimulus response at cellular level presents as the activation of Tumor Necrosis Factor (TNF)-ï•¡ and
  NF-ï•«B (Nuclear Factor-ï•«B), which results in the degradation of muscular protein. Curcumin is a yellow
  pigment substance commonly found in plants belonging to the genus Curcuma longa (kunyit) and Curcuma
  xanthorrhiza Robx (temulawak). One of the actions of Curcumin is inhibition of the NF-ï•«B pathway
  activation. The objective of this study was to analyze the effect of oral curcumin and immobilization on the
  diameter of skeletal muscle fiber of Rattus norvegicus. Subjects of the study were male Rattus norvegicus
  aged 3-4 months, with bodyweight of 150-200 grams. Subjects were divided into three groups, a control
  group,an immobilization group without curcumin, and an immobilization group with oral curcumin, each
  of which comprised 11 subjects. Immobilization using a splint was applied to the soleus muscle for 2 weeks.
  Oral curcumin was given to the immobilization group in a dose of 400 mg/rats (2 g/KgBW) single dose
  once a week. The diameter of soleus muscle was measured histopathologically with HE staining, under a
  light microscope using a magnification of 400x. Results showed that the diameter of skeletal muscle fiber in
  the immobilization group was reduced 42.41% and 26,48% in the immobilization group with curcumin
  supplementation the reduction was 26.48%, as compared to the control group. There was significant
  difference (p < 0.05) in the diameter of skeletal muscle fiber between control, immobilization, and
  immobilization with curcumin supplementation groups. In conclusion, the addition of oral curcumin
  significantly reduces atrophy of soleus muscle in rats immobilized for 2 weeks.

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• Walking ability and daily functioning in multiple sclerosis

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  Walking ability and daily functioning in multiple sclerosis

  Author(s)

  J.C.E. Kempen

  Date

  2013-03-21

  Source

  VU Amsterdam

  Multiple Sclerosis (MS) is a chronic progressive neurological disease, occurs most commonly in young adults and has a high prevalence in Western society.
  MS is characterised by the occurrence of lesions in diverse locations in the central nervous system and can thus cause a wide variety of neurological symptoms. These symptoms result in limitations in physical, social and cognitive functioning, and affect the activities of daily living. Long-term follow-up studies on the daily functioning of patients are therefore essential for effective healthcare and rehabilitation medicine. The first section of this thesis focused on a 10-year long-term follow-up study of an incident cohort of 156 patients with MS. The second section focused on reduced walking ability in MS patients. Among the many impairments due to neurological loss, one of the most frequently experienced is reduced walking ability. In order to gain a better understanding of the factors contributing to a reduced walking ability, the range of impairments that occur and that may affect gait must be correctly identified.
  From a clinical perspective, the aim was to unravel the various effects of neurological impairment on walking ability, in order to improve treatment opportunities.

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